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Taub in the News Archive

2018 - 2017 | 2017 - 2011

  • 2017
    November 17, 2017
    Drop-Off in Dementia in Northern Manhattan Echoes National Trend
    Dementia, including Alzheimer’s disease, is on the decline among northern Manhattan seniors, following national and global trends. The findings, by researchers at Columbia University Medical Center, were reported last month in the Journal of Alzheimer's Disease. The study found a 41 percent drop in dementia risk for seniors from Washington Heights and Inwood who joined a Columbia University-sponsored aging study in 1999 compared with a similar group that enrolled in 1992. Both groups included a multi-ethnic mix of non-Hispanic whites, African-Americans, and Hispanics. "It's important to look at a variety of populations so that we can determine if changes in dementia rates are occurring on a local, national, or global trend and to identify both common and population-specific factors that may be contributing to the overall picture," says James Noble, MD, assistant professor of neurology at Columbia University Medical Center (CUMC) and co-lead author of the study. "This is especially true in the U.S., where there are often racial, ethnic, and geographic disparities in health that are attributable to a variety of factors, from access to care to education." [read more]
    New York, NY (November 10, 2017) – Researchers at Columbia University Medical Center (CUMC) and the New York State Psychiatric Institute (NYSPI) may have discovered a way to use a patient's sense of smell to treat Alzheimer's disease before it ever develops. Having an impaired sense of smell is recognized as one of the early signs of cognitive decline, before the clinical onset of Alzheimer's disease. The researchers at CUMC and NYSPI have found a way to use that effect to determine if patients with mild cognitive impairment may respond to cholinesterase inhibitor drugs to treat Alzheimer's disease.

    The findings were published online this week in the Journal of Alzheimer's Disease.

    Cholinesterase inhibitors, such as donepezil, enhance cholinergic function by increasing the transmission of the neurotransmitter acetylcholine in the brain. Cholinergic function is impaired in individuals with Alzheimer's disease. Cholinesterase inhibitors, which block an enzyme that breaks down acetylcholine, have shown some effectiveness in improving the cognitive symptoms of Alzheimer's disease. However, they have not been proven effective as a treatment for individuals with mild cognitive impairment (MCI), a condition that markedly increases the risk of Alzheimer's disease.

    "We know that cholinesterase inhibitors can make a difference for Alzheimer’s patients, so we wanted to find out if we could identify patients at risk for Alzheimer's who might also benefit from this treatment," said D.P. Devanand, MBBS, MD, professor of psychiatry, scientist in the Gertrude H. Sergievsky Center at CUMC, and co-director of the Memory Disorders Clinic and the Late Life Depression Clinic at NYSPI. "Since odor identification tests have been shown to predict progression to Alzheimer's, we hypothesized that these tests would also allow us to discover which patients with MCI would be more likely to improve with donepezil treatment." [read more] [CUIMC NEWSROOM]

    Also covered by PsychCentral
    October 3, 2017
    Drugs Can't Stop Alzheimer's. A New Model of the Disease Explains Why.
    A new model of Alzheimer’s disease – proposed by scientists at Columbia University Medical Center and Weill Cornell Medicine – may explain why clinical trials of potential Alzheimer's drugs have a high failure rate. CUIMC NEWSROOM spoke with co-author Scott Small, MD, the Boris and Rose Katz Professor of Neurology, about the theory, published in a new article in Trends in Neuroscience. [read more]
  • SELF
    By Emily Rekstis
    August 28, 2017
    I Have a 50/50 Chance of Developing Huntington's Disease
    Featuring Jill Goldman
    It feels so certainly uncertain. I don't remember the exact moment I found out my dad had Huntington's disease, or how I found out it was genetic. What I do remember is showing off, in high school biology, that I knew the Huntington's gene was dominant in males. My reasoning was that my dad, his dad, and his granddad all had Huntington's. I knew my two sisters and I still had a chance at getting it, but it wasn’t as likely. This, of course, is not true...

    People at risk don’t have to live in this in-between world.

    The uncertainty can be put to rest by a not-so-simple genetic test. Jill Goldman, genetic counselor at the Taub Institute at Columbia University Medical Center, tells SELF that there is an international protocol which includes a DNA component that can reveal whether an individual will develop the disease. First, the person at risk will call an HD or movement disorder clinic to get information such as what the protocol entails, what the risks are, and what it costs. [read more]
    By David Noonan
    June 12, 2017
    Smell Test May Sniff Out Oncoming Parkinson's and Alzheimer's
    Featuring Dr. Davangere Devanand
    Sight and hearing get all the glory, but the often overlooked and underappreciated sense of smell—or problems with it—is a subject of rapidly growing interest among scientists and clinicians who battle Alzheimer's and Parkinson's diseases. Impaired smell is one of the earliest and most common symptoms of both, and researchers hope a better understanding will improve diagnosis and help unlock some of the secrets of these incurable conditions...

    "It's important, not just because it's novel and interesting and simple but because the evidence is strong," says Davangere Devanand, a professor of psychiatry and neurology at Columbia University. His most recent paper on the subject, a review, was published in The American Journal of Geriatric Psychiatry in December.[read more]
    Neuro-immunology Specialist

    Philip De Jager, PhD, MD, MMSc
    The Department of Neurology is very pleased to announce that Philip De Jager, PhD, MD, MMSc has joined our faculty as Professor of Neurology (in the Taub Institute for Research on Alzheimer's disease and the Aging Brain and the Columbia Precision Medicine Initiative). After graduating from Yale University with a degree in Molecular Biophysics & Biochemistry (as well as Medieval French literature), Dr. De Jager received a PhD in Neurogenetics from Rockefeller University and an MD from Cornell University Medical College before completing his MMSc in Clinical Investigation at Harvard Medical School (HMS) and MIT. He served as a neurology resident in the Partners Neurology Residency Program at the Massachusetts General Hospital and Brigham and Women’s Hospital. He then joined the faculty at HMS, rising to the rank of associate professor before joining CUMC. The goal of Dr. De Jager's work as a clinician-scientist is to apply modern methods of neuro-immunology, statistical genetics, and systems biology to the understanding of common neurodegenerative diseases. In Neurology, Dr. De Jager will serve as chief of a new Division of Neuro-immunology, which will include a new Center for Translational & Systems Neuro-immunology that he will direct, as well as the Multiple Sclerosis Clinical Care and Research Center, directed by Dr. Claire Riley. The focus of this new division will be to characterize and target the neuro-immunologic component of neurodegenerative disease. Please join us in welcoming Dr. De Jager to Neurology and CUMC!
  • CNBC
    March 15, 2017
    Brain Aging Linked to Common Genetic Variant
    A group of researchers has discovered a genetic variant that appears to have a significant impact on how quickly the brain ages in older people, and that may influence a person's risk of developing neurodegenerative diseases. The research was reported Wednesday in the journal Cell Systems. "If you look at a group of seniors, some will look older than their peers and some will look younger," said the study's co-author Asa Abeliovich in a news release. "The same differences in aging can be seen in the frontal cortex, the brain region responsible for higher mental processes." [read more]

    Also covered by Bioscience Technology, International Business Times, and Daily Mail.
    February 28, 2017
    Concussions More Likely in Female Athletes
    Female athletes appear to be more likely than men to suffer concussions during their careers on the field, a new study suggests.

    The findings add to the existing evidence that female athletes may be more susceptible to concussions, even as attention has tended to focus on the risk to male football players.

    "The more we look at concussion, the more we realize that women are at high risk," said study co-author Dr. James Noble. He's an assistant professor of neurology at Columbia University Medical Center in New York City... [read more]
    February 7, 2017
    Science & U!
    Editor's Note: In Segment 3, neurologist Dr. Richard Mayeux illuminates early onset dementia. [watch video]
    January 19, 2017
    In Alzheimer's, Excess Tau Protein Damages Brain's GPS
    Columbia University Medical Center (CUMC) researchers have discovered that the spatial disorientation that leads to wandering in many Alzheimer's disease patients is caused by the accumulation of tau protein in navigational nerve cells in the brain. The findings, in mice, could lead to early diagnostic tests for Alzheimer's and highlight novel targets for treating this common and troubling symptom.

    The study was published online today in the journal Neuron.

    An estimated three out of five people with Alzheimer's disease wander and get lost, usually beginning in the early stages of the disease, leaving them vulnerable to injury. Researchers suspect that these problems originate in an area of the brain known as the entorhinal cortex (EC). The EC plays a key role in memory and navigation and is among the first brain structures affected by the buildup of neurofibrillary tangles that are largely composed of tau, a hallmark of Alzheimer's disease. "Until now, no one has been able to show how tau pathology might lead to navigational difficulties," said co-study leader Karen E. Duff, PhD, professor of pathology & cell biology (in psychiatry and in the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain) at Columbia... [read more]

    Also covered by: Lab Chat (STAT), Genetic Engineering & Biotechnology News, Cosmos Magazine, Medical News, ScienceDaily, Medical News Today, Daily Mail, Mirror, PsyPost, Alzheimer's Reading Room, and Medical Xpress.
    By Allison Huseman
    January 5, 2017
    Familial Test Helps Detect Genes that Cause Complex Diseases
    Featuring Dr. Richard Mayeux
    A team of researchers at Baylor College of Medicine has developed a family-based association test that improves the detection in families of rare disease-causing variants of genes involved in complex conditions such as Alzheimer's. The method is called the rare-variant generalized disequilibrium test (RV-GDT), and it incorporates rare, as opposed to common, genetic variants into the analysis... [read more]
  • 2016
    November 22, 2016
    Live Web Chat: Understanding Alzheimer's Disease
    There is a lot of fear and confusion concerning Alzheimer's Disease. What is it exactly and how does it compare with other types of dementia? Can it be prevented or managed - and if there is no cure, why are research and early detection critical? [watch video]
    July 26, 2016
    Smell Test May Predict Early Stages of Alzheimer's Disease
    Researchers from Columbia University Medical Center (CUMC), New York State Psychiatric Institute, and NewYork-Presbyterian reported that an odor identification test may prove useful in predicting cognitive decline and detecting early-stage Alzheimer's disease. [read more]   [watch CBS New York video]

    Also covered by NPR: ""The whole idea is to create tests that a general clinician can use in an office setting," says Dr. William Kreisl, a neurologist at Columbia University."

    And by: CNN, Healio, Medscape, Immortal News, Science Daily, Medical Daily, Genetic Engineering & Biotechnology News, Nature World News, MedPage Today, PsychCentral.com, CTV News, and Business Standard.
    By Esther Landhuis
    July 26, 2016
    Could Trashing Junk Proteins Quash Alzheimer's, Parkinson's, ALS and Huntington's?
    Rather than going after proteins such as amyloid beta for Alzheimer's or alpha-synuclein for Parkinson's, one researcher has set on a different approach: "I settled on the idea that perhaps we should just get rid of as many abnormally folded, nasty-looking proteins as possible," says Karen Duff, a neuroscientist at Columbia University. [read more]
  • Enhancing Dentate Gyrus Function with Dietary Flavanols Improves Cognition in Older Adults
    Earlier this month, CBS News aired a feature on a joint, ongoing study by the Taub Institute (Drs. Scott Small and Adam Brickman) and the Division of Behavioral Medicine (Drs. Richard Sloan and Paula McKinley) on how dietary cocoa flavanols — naturally occurring bioactives found in cocoa —reversed age-related memory decline in healthy older adults. Previous results from a first study, published in Nature Neuroscience, provided the first direct evidence that one component of age-related memory decline in humans is caused by changes in a specific region of the brain and that this form of memory decline can be improved by a dietary intervention. These investigators are currently recruiting for another, larger study on the effects of cocoa flavanols.
    January 1, 2016
    Building a Better Brain
    The rule that "neurons that fire together, wire together" suggests that cognitive training should boost mental prowess. Studies are finding just that, but with a crucial caveat. Training your memory, reasoning or speed of processing improves that skill, found a large government-sponsored study called Active. Unfortunately, there is no transfer: Improving processing speed does not improve memory, and improving memory does not improve reasoning. Similarly, doing crossword puzzles will only improve your ability to do crosswords. "The research so far suggests that cognitive training benefits only the task used in training and does not generalize to other tasks," says neuroscientist Yaakov Stern of Columbia University. [read more]
  • 2015
    December 21, 2015
    Improving Brain's Garbage Disposal May Slow Alzheimer's Disease
    "A drug that boosts activity in the brain's "garbage disposal" system can decrease levels of toxic proteins associated with Alzheimer's disease and other neurodegenerative disorders and improve cognition in mice, a new study by neuroscientists at Columbia University Medical Center (CUMC) and New York State Psychiatric Institute (NYSPI) has found…" [read more]
    By Phoebe Magee
    The inspirational, nonprofit Arts & Minds organization, founded by Dr. Jamie Noble, is profiled in an article titled, "Picturing Alzheimer's", in the Winter 2015-2016 edition of Columbia Magazine. [read more]
    Researchers Study Alzheimer's Disease in People with Down Syndrome
    November 24, 2015
    "The risk of Alzheimer's disease–the most common cause of dementia–increases as a person ages. But the risk of Alzheimer's is increased dramatically for adults with Down syndrome." [read more]
    My Mother had Alzheimer's. Will my Fate be the Same?
    By Carol Berkower
    August 17, 2015
    "To understand my mother's disease and my own risk, I felt I needed to know what form of Alzheimer's she had, so I phoned Columbia University's Richard Mayeux. In 1985, Mayeux was the brilliant researcher who would find the cure for Alzheimer's disease if anyone could, according to my father. Mayeux was the reason my father drove my mother from our home in central New Jersey to Manhattan when her short-term memory failure grew so bad that she could no longer carry on a conversation.

    In the late 1980s, Mayeux co-founded what is now Columbia's Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Although he has yet to find a cure, Mayeux has discovered a great deal about how Alzheimer's is passed on from one generation to the next." [read more]
  • NPR
    Sharing Art Helps Medical Students Connect With Dementia Patients
    August 05, 2015
    "Hannah Roberts was a first-year-medical student at Columbia University College of Physicians in 2013 when she noticed her classmates were having an especially tough time relating to dementia patients…" [read more]
    Senate Special Committee on Aging: Finding an Alzheimer's Cure
    Dr. Richard Mayeux, chair of the Department of Neurology and co-director of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center, comments on the recent Senate Special Committee on Aging: Finding an Alzheimer's Cure. [view video]
    Unraveling the Complex Puzzle of Alzheimer's Disease
    February 11, 2015
    "Scott Small, director of Columbia's Alzheimer's Disease Research Center, the Boris and Rose Katz Professor of Neurology, discusses what is known and what's yet to be discovered, about the disease…" [read more]
  • 2014
  • CUMC
    Going Retro: Obscure Protein Complex Furnishes Fresh Clues for Alzheimer's Investigators
    By Andrea Crawford
    November 12, 2014
    "Columbia neurologist Scott Small, MD, was hot on the trail of a relatively unknown cellular AD illocomponent known as retromer and sure he was on to something big…" [read more]
    To Improve a Memory, Consider Chocolate
    By Pam Belluck
    October 26, 2014
    "Science edged closer on Sunday to showing that an antioxidant in chocolate appears to improve some memory skills that people lose with age…" [read more]
    Breakthrough Replicates Human Brain Cells for Use in Alzheimer's Research
    By Gina Kolata
    October 12,2014
    "For the first time, and to the astonishment of many of their colleagues, researchers created what they call Alzheimer's in a Dish…" [read more]
    Also covered by: BOSTON GLOBE
    Alzheimer's researchers hunt for new tools to identify disease's onset
    By Fredrick Kunkle
    July 13, 2014
    "A simple test of a person's ability to identify odors and noninvasive eye exams might someday help doctors learn whether their patients are at risk of Alzheimer's disease…" [read more]

    Also covered by:
    THE TELEGRAPH: Eye tests 'could spot' early Alzheimer's disease
    NBC NEWS: Worried You May Be Developing Alzheimer's? Check Your Eyes
    THE WALL STREET JOURNAL: Key to Detecting Alzheimer's Early Could Be in the Eye
    MEDICAL DAILY: Alzheimer's Early Detection May Soon Be Possible With Smell, Eye Exams
    "Researchers from Columbia University's Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Departments of Neurology, Epidemiology, and Systems Biology are part of a five-university collaboration receiving a $12.6 million, four-year grant from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH), to identify rare genetic variants that may either protect against or contribute to Alzheimer's disease risk." [read more]
    Potential Alzheimer's Drug Spurs Protein Recycling
    By Ken Garber
    April 25, 2014
    "Small's discovery that retromers are lacking in the precise area of the brain first affected by Alzheimer's disease offered a possible solution to one of the condition's biggest puzzles…" [read more]

    Also covered by:
    CUMC NEWSROOM: "Chaperone" Compounds Offer New Approach to Alzheimer's Treatment
    Aging and the Changing Landscape of Memory
    April 9, 2014
    "We now know that the dentate gyrus is important for a particular kind of memory called pattern separation, which allows us to distinguish things that are similar, like faces, but also clearly distinct," says Dr. Small [read more]
    Ever-So-Slight Delay Improves Decision-Making Accuracy
    March 7, 2014
    "Columbia University Medical Center (CUMC) researchers have found that decision-making accuracy can be improved by postponing…" [read more]
    The Mediterranean Diet and Cognition
    By Lindsey Getz
    February 4, 2014
    "Growing evidence suggests that following this eating pattern may improve memory and prevent neurodegenerative disease…" [read more]
  • 2013
    Is It Alzheimer's?
    By Richard W. Besdine, M.D.
    January 9, 2013
    "…neurologist Scott Small, M.D., Ph.D., a Beeson scholar and recipient of a Hartford/AFAR Collaborative Research Award, published direct scientific evidence of the neurological difference between memory loss and Alzheimer's." [read more]
    Study Shows Where Alzheimer's Starts and How It Spreads
    December 22, 2013
    "Using high-resolution functional MRI (fMRI) imaging in patients with Alzheimer's disease and in mouse models of the disease, Columbia University Medical Center (CUMC) researchers have clarified three fundamental issues about Alzheimer's…" [read more]
    Video games may help fend off senior moments
    November 27, 2013
    "At age 70, Allan S. is not a gamer, but when his time comes to play Space Fortress for a Columbia study on the aging brain, he eagerly takes his seat in front of a computer monitor…" [read more]
    New Method Could Predict When Alzheimer's Patients Will Need Extensive Assistance, Pass Away
    By Rebekah Marcarelli
    November 7, 2013
    "A new method could predict the distance in time between when an individual is diagnosed with Alzheimer's to when they will need extensive assistance." [read more]

    Also covered by: MEDICAL XPRESS and CUMC
    11 new gene variants linked to Alzheimer's disease
    By Michelle Castillo
    October 28, 2013
    "In the largest genetic analysis of Alzheimer's ever completed, scientists have discovered 11 new genes that may be tied to the late-onset form of the dementia…" [read more]
    Scientists find clue to age-related memory loss
    By Lauran Neergaard
    August 28, 2013
    "Scientists have found a compelling clue in the quest to learn what causes age-related memory problems, and to one day be able to tell if those misplaced car keys are just a senior moment or an early warning of something worse." [read more]

  • NPR
    New Alzheimer's Research Could Lead To Treatments
    By Carey Goldberg
    July 25, 2013
    "A new report in the journal Nature shows a significant step forward in figuring out what causes things to go wrong in the brain early on in Alzheimer's disease…" [read more]

    Path of Alzheimer's Disease Risk Gene Tracked, Scientists Say
    By Elizabeth Lopatto
    July 24, 2013
    "Scientists mapped the step-by-step actions that lead to late-onset Alzheimer's disease…" [read more]
    N.C. A&T Alzheimer's Study Targets Blacks, The Group Most Affected by the Disease
    By Katti Gray
    July 16, 2013
    "… study aims to discover why Alzheimer's strikes Blacks more than any other racial group in the United States." [read more]
    Could family longevity protect against dementia?
    By Andrew M. Seaman
    May 6, 2013
    "It's not necessarily that these individuals never become cognitively impaired, but what it seems like is that there is a delayed onset of cognitive impairment," said Stephanie Cosentino, of the Columbia University Medical Center in New York. [read more]
    Alzheimer's: The Costliest Killer
    By Peter Coy
    April 25, 2013
    "In 2006 former television journalist Meryl Comer described in the Alzheimer's & Dementia journal what it's like to care for a husband with early-onset Alzheimer's disease …" [read more]
    Alzheimer's gene ABCA7 linked to increased disease risk in African-Americans
    By Ryan Jaslow
    April 10, 2013
    "A new study has revealed that a gene that was once thought to be weakly associated with Alzheimer's disease risk in white people may almost double the risk of developing the debilitating neurological disease when it's present in African-Americans…" [read more]

    Also covered by:
    NBC NEWS: Study Finds Gene that May Raise Alzheimer's Risk in Blacks
    USA TODAY: Gene Linked to Higher Alzheimer's Risk in Blacks
    NEW YORK TIMES: In Blacks, Alzheimer's Study Finds Same Variant Genes as in Whites
    BLOOMBERG NEWS: Gene Doubles Risk of Late-Onset Alzheimer's in Blacks
    REUTERS: Study Finds Gene that may Raise Alzheimer's Risk in Blacks
    WNYC RADIO: Study Finds Black and White Alzheimer's Patients Share Genes Variants
    HEALTHDAY NEWS: Gene May Double Risk of Alzheimer's in Blacks
    MEDPAGE TODAY: Gene Mutation in Blacks May Raise Alzheimer's Risk
    ALZHEIMER RESEARCH FORUM: AD GWAS in African Americans Confirms, Reshuffles AlzGene List
    Assessing Your Risk of Alzheimer's Disease
    By Michelle Andrews and Kaiser Health News
    April 4, 2013
    "Alzheimer's disease can't be prevented or cured, and it ranks second only to cancer among diseases that people fear…" [read more]
    Depression in Alzheimer's Patients Associated with Declining Ability to Handle Daily Activities
    March 19, 2013
    "More symptoms of depression and lower cognitive status are independently associated with a more rapid decline in the ability to handle tasks of everyday living…" [read more]

    Also covered by:
    DAILY RX: Depression Put Alzheimer's on Fast Track
    Brain Lesions May Play Role in Alzheimer's
    Michael Smith
    January 23, 2013
    "In a cohort of participants in the Alzheimer's Disease Neuroimaging Initiative, the two factors were independent predictors of Alzheimer's disease, according to Adam Brickman, PhD, of Columbia University…" [read more]

    Also covered by:
    HEALTH CANAL.COM: It's Not Just Amyloid: White Matter Hyperintensities and Alzheimer's Disease
    Four Steps Against Alzheimer's
    By Linda Marsa
    January 23, 2013
    "Alzheimer’s disease has repeatedly defeated predictions that effective treatments were right around the corner. … But several 2012 advances improve the prospects for intervening …" [read more]
    Discontinuing Risperidone?
    By Mary Ann Moon
    January 22, 2013
    "Among patients with Alzheimer's disease who develop psychosis or agitation-aggression that responds to risperidone, discontinuing the drug as advised after 3-6 months is associated with a doubling of the rate of relapse…" [read more]
  • 2012
  • Arlene Lawton, RN has been selected to receive the 2012 P&S Award for Excellence in Research. As her many nomination letters attest, Arlene "has been an example of excellence in research for over 20 years." As a research nurse at the Alzheimer's Disease Research Center (ADRC), coordinator for our Brain Donation program, and senior staff associate in the Taub Institute, Arlene has made a "lasting impression on countless individuals," "broaching difficult topics with extraordinary grace," and treating patients and colleagues alike with "genuine warmth and kindness" in a "poised and professional" manner.
  • Dr. Yaakov Stern was one of several notable panelists to participate in the Alzheimer's Association Annual Meeting presentation, "Crosswords, Computers, and Cognition: What's Going on in Your Brain?", now available online. With nearly 400 people crowding the Times Center auditorium, this event was the most well-attended in the New York City chapter's history.
  • Dr. Larry Honig's recent Archives of Neurology publication on telomere length is the subject of CUMC's latest Research Capsule. [read more]
  • "Researchers in the Taub Institute at Columbia University Medical Center (CUMC) have identified a mechanism that appears to underlie the common sporadic (non-familial) form of Parkinson's disease…" [read more]
  • Dr. Manly's work on the "Early Detection of Alzheimer's among Diverse Populations" is the topic of Columbia University Medical Center's Research Capsule.
  • Drs. Wai Haung Yu and Jessica Wu of the Taub Institute received awards from the American Health Assistance Foundation for "Tau Homeostasis Via Proteasomal & Autophagic Activity" and "Conformation-Dependent Uptake and Secretion of Tau," respectively.
  • Frontotemporal Dementia (FTD) is a group of poorly-understood, frequently misdiagnosed brain diseases that can result in drastic personality changes in affected individuals. Columbia Neurology FTD expert Dr. Edward Huey and Genetic Counselor Jill Goldman were recently featured in an in-depth New York Times article titled, "When Illness Makes A Spouse A Stranger," which chronicles one couple's courageous battle with this devastating neurological disorder.
  • A new study by Dr. Nikolaos Scarmeas has found that consumption of omega-3 fatty acids, plentiful in fish and nuts, is associated with lower blood levels of beta-amyloid protein… read more in The New York Times.
  • Dr. Scott Small and colleagues from Neurology and the Taub Institute examined the association of depressive symptoms, antidepressant use and brain volumes on MRI, in a large cohort of nondemented, elderly individuals from the Washington/Hamilton Heights-Inwood Columbia Aging Project (WHICAP). Their results, currently published online in the Journal of Alzheimer's Disease, suggest that late life depression is associated with more global brain atrophy, more atrophy of the hippocampus, and more white matter lesions, mainly driven by antidepressant use.
  • Drs. Roy Alcalay, Nikolaos Scarmeas, and others from Neurology and Taub Institute found Mediterranean-style diet adherence to be associated with reduced odds for Parkinson's disease (PD). Their study, currently published in an online version of Movement Disorders, also suggests an association between higher MeDI adherence and later PD age at onset.
  • Dr. Scott Small on recent developments in Alzheimer's, featured on Charlie Rose.
  • Dr. Adam Brickman on "Silent Strokes Tied to Memory Loss Among Older Adults," featured on Voice of America, USA Today.
  • Drs. Karen Duff, Scott A. Small, and Li Liu on "Path Is Found for the Spread of Alzheimer's," featured in The New York Times.
  • Dr. Jennifer J. Manly on "US wants effective Alzheimer's treatment by 2025," featured in the Associated Press.
  • The work of Dr. Scott Small and colleagues from Neurology and the Taub Institute, that implicated the polyamine pathway in Parkinson's disease pathogenesis, was highlighted in Chapter 1 of the NIH's Clinical and Translational Science Awards Progress Report 2009 – 2011. [read report]
  • Dr. Adam Brickman, was selected to receive the Early Career Award from the International Neuropsychological Society. He will be delivering an award address titled "Reconsidering the Role of White Matter Disease in Cognitive Aging and Dementia" at the 40th annual meeting of the Society next month in Montreal.
  • Bernadette Boden-Albala, DrPH, Department of Neurology, and Jose Luchsinger, MD, Taub Institute, have received $3.9 million over five years from the National Institute on Minority Health and Health Disparities for "Northern Manhattan Initiative for Minority Involvement in Clinical Trials (NIMICT)."
  • Eric A. Schon, PhD, Lewis P. Rowland Professor of Neurology in Genetics and Development has received an award from the Alzheimer's Drug Discovery Foundation for his project, "Mitochondria-Associated Membranes in the Pathogenesis of Alzheimer's Disease: A New Target for Drug Discovery."
  • Dr. Adam Brickman, has been selected to receive the 2011 Margaret M. Cahn Research Award, for his research on white matter hyperintensities in aging and Alzheimer's disease, from the Alzheimer's Association Hudson Valley/Rockland/Westchester, NY Chapter.
  • Elan Louis, MD, MS, Professor of Neurology and Epidemiology answers questions on "the essentials of essential tremor" in the most recent P&S Five in Five series. [watch the video]
  • Yaakov Stern, PhD, Professor of Clinical Neuropsychology in the Departments of Neurology, Psychiatry, and Psychology has been awarded a new RO1 and two 5-year renewals from the NIH for his projects: "Exploring Cognitive Aging Using Reference Ability Neural Networks"; "Predictors of Severity in Alzheimer's Disease"; and "Imaging of Cognition, Learning, and Memory in Aging."
  • Edward D. Huey, MD, Assistant Professor of Psychiatry and Neurology and Jill Goldman, MS, MPhil, Genetic Counselor, both in the Taub Institute, are co-directing a CME program, "Is it Alzheimer's Disease or Frontotemporal Degeneration? An Update on Diagnosis, Management, and Research," on Monday, December 12, 12:15-4:45 PM, in the NI Auditorium.
  • Scott Small, MD, Professor of Neurology in the Taub Institute and Sergievsky Center and colleagues have reviewed recent neuroimaging findings that indicate common brain disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression, differentially target distinct functional and molecular subregions of the hippocampus, suggesting a unified pathophysiological framework of hippocampal dysfunction.
  • Karen Marder, MD, MPH, Sally Kerlin Professor of Neurology and Psychiatry was appointed as one of three site investigators to serve on the Executive Committee of the NINDS NeuroNEXT project. The NeuroNEXT network of 25 sites nationwide, including Columbia in partnership with Weill-Cornell, will provide a standardized, accessible infrastructure to facilitate rapid development and implementation of protocols in adult and pediatric neurological disorders.
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