Dr. Lawrence Honig's principal medical and scientific interests are in aging and neurodegenerative diseases of the brain. These latter include Alzheimer's disease, Lewy Body dementia, vascular cognitive impairment, and Creutzfeldt-Jakob disease, and also include the frontotemporal degeneration disease family including corticobasal degeneration, ALS-dementia, and progressive aphasia. His laboratory efforts are concentrated on molecular processes that occur in aging and degenerative brain diseases, including changes in chromosomal telomeres, and changes involved in protein processing and in the losses of nerve cells and their connections, the synapses. His research involves analysis of changes in human blood, fluid, and tissues, as well as the use of model systems including mice and cell culture. In addition to his laboratory investigations, he carries out clinical research on diagnosis, imaging, and drug treatment trials of patients with Alzheimer’s disease and other degenerative brain conditions.