Dr. Vardarajan is bioinformatician by training, and his primary interests is to understand the role of genetic variation in the biology of neurodegenerative diseases, in particular, Alzheimer’s disease. His research group applies computational approaches for gene discovery in Alzheimer's disease (AD) in multi-ethnic populations. Dr. Vardarajan’s team is involved in several multi-institutional studies of genetics of AD including the Alzheimer’s Disease Sequencing Project (ADSP). He is applying computational pipelines to characterize structural variation in large scale sequencing data for gene discovery in Alzheimer’s disease. Dr. Vardarajan also leads multi-omics integration of genetic, transcriptomic, proteomic, metabolomics data for gene and pathway discovery in multiple cohorts including the EFIGA (Caribbean-Hispanic families) and WHICAP (Washington Heights-Inwood Columbia Aging Project).