Research Summary:

I am the founding Director of the Stem Cell and Cellular Models Platform at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, a core facility that was established with the goal to implement pluripotent stem cell technology as a resource for neurodegenerative and neurological disease researchers at Columbia University. Our laboratory's main focus is developing robust differentiation protocols for large-scale production of disease-relevant neurons and other CNS cell types, and using gene-editing strategies to create allelic series of isogenic disease and control pluripotent stem cell (PSC) lines. These tools will greatly aid mechanistic studies of disease mechanisms and provide a better platform for therapeutic screening. In addition to partnering with a variety of Taub investigators on disease-related research, our laboratory is interested in elucidating novel mechanistic links between aberrant APP processing and Tau dysregulation.

Education and Training:

PhD: Columbia University, 2008